灯盏花素治疗冠心病的疗效观察

Clinical Observation on Effect of Breviscapin in Treating Patients of Coronary Heart Diease

目的：探讨灯盏花素治疗冠心病的疗效机理．方法：用灯盏花素治疗冠心病伴高粘滞血症患者４０例，与用复方丹参注射液治疗的同样患者４０例进行对比，两组疗程均１５天．对血清脂质过氧化物（ＬＰＤ）含量、超氧化物歧化酶活性（ＳＯＤ）、血脂、血液流变学指标进行检测．结果：患者症状、心电图、血脂、血流变、ＬＰＯ、ＳＯＤ，治疗组较对照组改善明显．（ｐ＜０．０５）．结论：灯盏花素降低冠心病者血液的高粘滞状态，提高抗氧化能力，有效改善其症状．

Objective: To explore the therapeutic effect and mechanism of Breviscapin on coronary heart disease. Methods: 40patients with CHD complicated with hyperviscosity were treated with Breviscapin for a period of 15 days as the Breviscapin group, and the 40 patients with salvia. injection were taken as the control group. The therapeutic efficacy and effect of treatment on plasma Lipid peroxide(PLO) content, Superoxide dismutase (SOD) activity, blood lipids emorrheologic indexes Were observed. Besults: The Breviscapin group was better in Clinical concomitant symptoms relieved and EKG improvement than those in the control group (P<0.05 or p<0.01). Markedly improvement of laboratory findings occurred in both groups (P<0.05) but the changes of some parameters. such as LPO, SOD total cholesterol(TC), low-shear blood viscosity in the Breviscapin group. (P<0. 05). Conclusion: Breviscapin could reduce the blood hyperviscosity, increase antioxidative energy and improve sysmptoms of CHD effectively.