槐定碱抗心律失常作用的实验研究

Antiarrhythmic effect of saponines of leaf of sophoridine, (Sop)

槐定碱(Sophoridine,Sop)10mg/kg、20mg/kg能明显对抗乌头碱20μg/kg,,BaCl2和结扎左冠状动脉前降支诱发大鼠的室性心律失常.Sop也能明显对抗CaCl2-Ach(CaCl20.6％+Ach 0.0025％)混合液诱发小鼠心房纤颤或扑动.Sop 10mg/kg对大鼠心电图实验,证明有负性频率作用,负性传导作用.这些作用可能是Sop抗心律失常作用的药理基础.

Sophoridine(Sop) 10mg/kg, 20mg/kg could inhibit markedly the ventricular arrhythmias induced by aconitine 20 μg/kg and BaCl2 2 mg/kg and coronary ligation in rat. It also obviously reduced the incidence of atrium fibrillation produced by CaCl2 Ach (CaCl20.6%+Ach 0.0025%) 10 mg/kg in mice. These actions were similar to Quinidine. The ECG of rates was significantly P-R changed after i. v of Sop 10mg/kg. Hearts are reduced. The P-R and Q-T intervals are prolonged.