Graves病患者促甲状腺素受体抗体的变化

Changes in serum thyrotropin receptor antibody in patients with Graves disease

目的 :探讨Graves病患者促甲状腺素受体抗体 (TRAb)的变化。方法 :应用放射免疫分析法 ,对 12 7例Graves病患者TRAb进行测定。结果 :病情未缓解组TRAb水平显著高于缓解组 (P <0 .0 0 1)。不限碘盐治疗Graves病组TRAb水平显著高于正常对照组 (P <0 .0 0 1)。结论 :TRAb测定在限碘盐治疗Graves病、评估抗甲状腺药物疗效及在确定停药。

Objective:To investigate the changes in serum thyrotropin receptor antibody(TRAb) in patients with Graves disease.Methods:One hundred and twenty seven patients with Graves disease were tested for TRAb by radioimmunoassay.Results:The study showed that the level of TRAb in the disremisson group was higher than that in the remission group( P <0.001).Compared with normal,the level of TRAb was increased in non iodine salt treated patients with Graves disease( P <0.001).Conclusions:It suggests that TRAb measurement is of value in initiating non iodine therapy for patients with Graves disease,evaluating the effect of the anti thyroid gland drugs,deciding the time to stop therapy and predicting the relapse.