厄贝沙坦对高血压的降压作用及逆转左心室肥厚的疗效观察

Clinical observation of irbesartan for depressurized hypertension and reversal left ventriculus pachynsis

目的 :观察厄贝沙坦的降压疗效及其逆转左心室肥厚的作用。方法 :高血压患者 5 0例 ,给予口服厄贝沙坦 15 0mg ,每天 1次 ,治疗 6周后观察疗效。对其中 2 1例伴左心室肥厚者给予连续服药半年 ,用彩色多普勒超声心动图观察心脏结构有否改变。结果 :5 0例高血压患者治疗 6周后收缩压和舒张压均较治疗前明显下降 (P <0 .0 1)。合并左心室肥厚的 2 1例患者治疗半年后 ,室间隔厚度 (IVST)、左房内径 (LAD)、左室舒张末期内径 (LVDd) ,均较治疗前显著减小 (P <0 .0 1) ,左室射血分数(LVEF)明显改善。治疗过程中未见明显的不良反应。结论

Objective:To investigate the effects of irbesartan for depressurized hypertension and reversal left ventriculus pachynsis.Methods:Fifty cases of hypertension with application of irbesartan,the results were observe after six weeks.Of twenty one cases with left ventriculus pachynsis,the cardiac structures were observe by chromatic doppler ultrasonic cardiogram after six months of continuative dose.Results:Among all 50 hypertensions patient contractive and diastolic pressure decreased obviously six weeks after treating than that before treating( P <0.01).In 21 patients merge left ventricle thick treats the half a year,interventricular septal thickness(IVST),left atrium directly(LAD),left ventricle diastasis directly(LVDd),significantly reduced than before treating( P <0.01) and the left ventricle ejection fraction(LVEF) obviously improvemed.During treatment there were no any obvious bad reaction.Conclusions:Irbesartan can significant reverse left ventriculus pachynsis of hypertension when depressurizing.