丙溴磷对家兔SOD、CAT、GSH-Px影响的实验研究

An experimental study of the effects of profenofos on antioxidase in rabbits

为探讨丙溴磷对SOD、CAT、GSH Px的影响及其意义 ,将家兔随机分为A组 (高剂量组 )、B组 (低剂量组 )、C组 (对照组 ) ,分别于染毒不同时间测定血浆超氧化物歧化酶 (SOD)、过氧化物酶 (CAT)、谷胱甘肽过氧化物酶 (GSH Px)等指标 ,同时测定全血胆碱酯酶 (ChE)活力。结果显示 ,A组、B组SOD、CAT、GSH Px与同组染毒前及对照组相比显著升高 (P <0 0 5和P <0 0 1) ,ChE与同组染毒前及对照组相比降低或显著降低(P <0 0 1) ,且ChE的显著降低发生于抗氧化酶指标显著升高之后。结果提示 ,丙溴磷可致SOD、CAT、GSH Px等抗氧化酶活性增高 ,可能造成脂质过氧化的增强 ,并可能是丙溴磷早期中毒的表现之一。

In order to explore the effects of superoxide dismutase(SOD), catalase(CAT), glutathione-peroxidase(GSH-Px) in rabbits exposed by profenofos and its meaning. 18 rabbits were divided into three groups randomly: A group(high-dose group),B group(low-dose group),C group(control group),each group including 6 rabbits. The activities of SOD, CAT, GSH-Px in plasma,and cholinesterase(ChE) in blood were measured in different exposure period. The results showed that activities of SOD ,CAT and GSH-Px increased, ChE decreased markedly compared with those in the same group before experiment and control group (P<0.05,P<0.01).The incease of antioxidase activities was earlier than the decease of ChE activity. It suggests that profenofos can result in the increases of the activities of SOD, CAT and GSH-Px, which may be earlier diagnostic index in profenofos poisoning.