稀土元素钇对子代小鼠体内痕量元素的影响

Effect of the long-term intake of yttrium in drinking water on trace elements in F1 generation mice

探讨了稀土元素Y的长期摄入对子代小鼠脑、内脏组织中某些痕量元素及脑中Y含量的影响 ,以期为稀土生物效应的研究提供新的思路和数据。通过在饮水中加入稀土Y(0、2 3 2 5和 2 32 5 0 0mg L)使小白鼠长期摄入稀土 ,7个月后用ICP MS法和原子荧光法测定F1子代小鼠脑组织中微量元素Cu、Cd、Pb和Y以及脑、肝、脾、肾中Se的含量。结果显示 ,F1子代小鼠高浓度稀土负载组脑组织中稀土Y含量、脾脏中Se含量显著增加 (P <0 0 5 ) ;肝、肾中Se也有增加趋势 ,但无显著差异 ;脑组织中Cu、Cd、Pb并无明显变化 ;低浓度稀土负载组脾脏中Se含量显著增加 (P <0 0 5 )。提示稀土钇可进入幼鼠脑组织中 ;稀土的长期摄入不会增加Cd、Pb等有害元素的摄入和吸收 ;

The effects of the long-term intake of yttrium on trace elements in tissues and yttrium in brain of F1 generation mice were studied so as to elucidate some physiological function of the rare earths. The mice were fed with Y 3+ (0, 23.25mg/L, 2325.00 mg/L) dissolved water at different levels for seven months. The level of trace elements such as Cu, Cd, Pb and Y in brain and Se in brain, liver, spleen and kidney of F1 generation mice were measured by ICP-MS and atom fluorescent method. The results showed that, compared with control mice, significant changes in content of Se (P<0.05) in spleen and Y (P<0.05) in brain were observed, but no changes were found in content of Pb, Cd, and Cu in brain for the high dose group, and an increase was detected in content of Se(P<0.05) in spleen for the low dose group, suggesting that long-term intake of Y 3+ might enhance the absorption of Se in some tissue that might be one of the biological effect of rare earth and, Y 3+ might enter young mammalian brain.