纳洛酮治疗急性重症颅脑外伤的临床观察

Clinical study of naloxone in the treatment of acute severe brain injury

目的探讨纳洛酮在急性重症颅脑外伤中的应用效果及其机理。方法GCS 3～ 8分患者 38例为治疗组 ,采用纳洛酮治疗 ,另以 39例作为对照组。观察意识、生命体征变化及远期疗效。结果治疗组意识改善及远期恢复良好率明显高于对照组 ,使用呼吸机的时间及住院日缩短 ,重残及病死率明显减少。结论纳洛酮能有效促醒和明显降低急性重症颅脑外伤患者的病死率 ,改善预后等。

Objective To explore the clinical effects and mechanism of naloxone in treating acute severe brain injuries. Methods 38 cases with GCS3-8 points, as treatment group, were treated with naxolone and other 39 cases were taken as control group, whose consciousness, signs and symptoms and long-term therapeutic effect were observed.Results The consciousness improvement and long-term recovery rate in the treatment group was remarkably higher than that in the control group. The disability rate and mortality rate declined significantly. The duration of using respirator and the hospitality time were all shortened. Conclusion Naloxone can improve the recovery of coma and significantly reduce mortality and morbidity rates and improve prognosis of acute severe brain injury.