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蛋白质二级结构中同义密码子与氨基酸上下文关联的偏好型

Preference Context of Synonymous Codon and Amino Acid in the Protein Secondary Structure
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摘要 通过对人(Homosapiens)的117个蛋白质和大肠杆菌(E.coli)的87个蛋白质的统计分析,发现mRNA序列中的同义密码子与氨基酸的上下文关联是和蛋白质二级结构有关的,并给出了各二级结构中有意义的上下文关联型.讨论了该结果对蛋白质结构预测的改进意义及其在基因工程领域可能的应用. The context of synonymous codon and amino acid in mRNA sequence is related to the secondary structure of protein by analyzing the structure of 117 human proteins and 87 E.coli proteins statistically.The context correlations in different secondary structures are given.The results which can provide the massages in prediction the secondary structure of proteins,and prospective applications in the field of gene engineering are discussed.
作者 胡秀珍 肖奕
机构地区 内蒙古大学物理学系 华中科技大学物理系
出处 《内蒙古大学学报（自然科学版）》 CAS CSCD 北大核心 2003年第6期636-640,共5页 Journal of Inner Mongolia University：Natural Science Edition
基金 内蒙古自然科学基金(20001301) 内蒙古大学校基金资助项目
关键词 蛋白质二级结构 同义密码子 统计关联 氨基酸序列 MRNA序列 secondary structure of protein synonymous codon statistical correlation amino acid sequence mRNA sequence
分类号 Q61 [生物学—生物物理学]
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参考文献11

  • 1Oresic M,Shalloway D. Specific correlations between relative synonymous codon usage and protein secondarystructure [J]. Mol Biol. , 1998,281 z 31~48.
  • 2Xie T,Ding D F. The relationship between synonymous codon usage and protein structure [J]. FEBS,Letters,1998,434z91~96.
  • 3Adzhubei I A, Adzhubei A A, Neidle S. An Integrated Sequences-Structure Database incorporating matchingmRNA sequence, amino acid sequence and protein three-dimensional structure data EJ]. Nucleic Acids Res,1998,26z327~331.
  • 4Adzhubei I A, Adzhubei A A. ISSD Version 2.0 .. tazonomie range extend [J]. Nucleic Acids Res. , 1999,27 .. 268~27.
  • 5Kabsch W,Sander C. Dictionary of protein secondary structure :Pattern recognition of hydrogen-bonded and ge-ometrical features ~J:]. Biopolymers, 1983,22: 2577~ 2637.
  • 6Shpaer E. Constraints on codon context in Escherichia coli genes :their possible role in modulating the efficiencyof translation [J]. J. Mol Biol. , 1986,188 : 555~ 564.
  • 7Shpaer E G. The secondary structure of mRNAs from Escherichia coil :Its possible role in increasing the accura-cy of translation D~]. Nucleic Acid Res, 1986,13 .. 275~ 288.
  • 8Zhang J, Liu C Q, Lai L H, et al. Messenger RNA probably carrias the three dimensional genetic informationD~. Zoology Research, 1997,18 (2) : 138.
  • 9Li H,Luo L F. The RElation between Codon Usage,Base Correlation and Gene Expression Level in EscherichiaColi and Yeast [J].J,Theor Biol. ,1996,181z111~124.
  • 10Sharp P M,Li W H. Codon usage in regulatory genes in Escherichia coli does not reflect selecton for rarecodons CJ'I. Nucleic Acids Res, 1986,14 .. 7737~ 7749.
内蒙古大学学报（自然科学版）
2003年 第6期

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