儿童幽门螺杆菌感染危险因素的病例对照研究

Case-control study on risk factors of helicobacter pylori infection among preschool children

目的 探讨学龄前儿童幽门螺杆菌 (Helicobactrepylori,H pylori)感染的危险因素。 方法 以 2 0 0 1年 5～ 6月在浦城县实验幼儿园所检查中确诊的H pylori感染儿童 64例为病例组 ,以同期检查的未感染H pylori儿童为对照组 ,进行 1∶2配对的病例对照研究。结果 条件Logistic回归分析筛选出学龄前儿童H pylori感染的 5个危险因素 :即平时照顾小孩的人有胃病史 (OR =4 95) ;平时有啃手指、玩具、文具的习惯 (OR =4 74) ;低人均居住面积 (OR=3 73 ) ;襁褓中接受口嚼食物喂养 (OR =3 3 6)和与成人共用一个刷牙口杯 (OR =2 40 )。结论 儿童幽门螺杆菌感染呈现家庭内聚集 ,且与儿童个人卫生习惯、居住条件呈密切相关。积极防治成人的H pylori感染、改善生活居住状况、教育小儿从小养成良好的饮食和卫生习惯对降低儿童H

Objective To identify risk factors of helicobacter pylori infection in preschool children.Methods During May to June in 2001,a case-control study was conducted.64 children who were H.pylori-infected were recruited and matche d them with 128 children of the same age and sex from the same class who were H. pylori uninfected.Results Logistic regression analysis demonstrated signifi cant independent relationships between H.pylori infection and the following fact ors:stomach trouble of the adults who looked after the child ( OR =4 95);the bad habits of gnawing fingers or toys ( OR =4 74);crowding ( OR =3 73);acc epting chewed food by adults in one's infancy ( OR =3 36);toothcup-sharing with other family members in the home ( OR =2 40).Conclusion H.pylori infection clusters within families an d H.pylori infection was often acquired in childhood by oral-oral and fecal-or al person to person spread.Personal hygiene practices and living condition were also involed in the transmission of H.pylori to children.