膀胱癌患者血清及尿中L-selectin检测的临床意义

Detection and quantification of serum and urine L-selectin in patients with bladder transitional carcinoma

目的 探讨膀胱移行细胞癌 (TCC)患者检测血、尿细胞粘附因子L selectin的临床意义。 方法 采用ELISA法测定 46例膀胱癌患者 (浸润性 2 0例 ,浅表性 2 6例 )及 14例良性前列腺增生患者血清及尿L selectin浓度。 结果 3组患者术前L selectin血清浓度分别为 :浸润性癌患者 ( 76 6 .3± 135 .1)ng ml,浅表性癌患者 ( 5 6 3.8± 118.2 )ng ml,良性前列腺增生患者 ( 5 44 .1± 12 1.2 )ng ml。浸润性癌组与浅表性癌组及良性增生组分别比较 ,差异有显著性意义 (P <0 .0 1)。浸润性癌患者术后血清L selectin浓度显著低于术前 (P <0 .0 5 )。浸润性癌组术前尿L selectin水平显著高于浅表癌组及良性前列腺增生组 (P <0 .0 1)。 结论 血、尿L selectin浓度水平与TCC浸润程度有关 ,对TCC患者治疗前临床分期及选择手术方案有参考价值。

ObjectiveTo investigate and eveluate the significance of serum and urinary L-selectin in patients with transitional cell carcinoma.MethodsSerum and urinary samples were obtained before operation and 6 days after surgery from 46 patients with transitional cell carcinoma of bladder and from 14 patients with benign prostate hyperplasia.The serum and urinary L-selectin levels were measured using ELISA.ResultsThe preoperative serum concentration of L-selectin was significantly higher in patients with invasive bladder cancer [(766.3±135.1)ng/ml] than those with superficial bladder cancer [(563.8±118.2)ng/ml],P<0.01 and benign prostate hypertplasia patients [(544.1±121.2)ng/ml],P<0.01.In addition,the postoperative serum concentration of L-selectin was significantly lower than preoperative levels in patients with invasive bladder cancer (P<0.05) .Preoperative urinary L-selectin level in patients with invasive bladder cancer was also significantly higher than patients with superficial cancer or benign prostate hypertplasia.ConclusionsThe results suggested that serum and urinary L-selectin level is correlated with progression of TCC,L-selectin may play an impontant role in evaluating the clinical stage and treatment of TCC and may be helpful in monitoring bladder tumor development.