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细胞因子在Graves眼病发病中的作用机理 被引量:4

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摘要 Graves眼病(GO)与甲状腺自身免疫反应之间的关系尚未完全明了,甲状腺抗原可能是它们的主要桥梁,细胞因子在其中也发挥很重要的作用。GO急性期以Th1型细胞因子如干扰素(IFN)-γ、白介素(IL)-1、IL-2、转化生长因子(TGF)-β或肿瘤坏死因子(TNF)-α等产生为主,与眼外肌增大有关,是致免疫细胞因子;慢性期以,Th2型细胞因子如IL-4、IL-6及IL-10等产生为主,累及球后脂肪组织,是抗免疫细胞因子。因此,急性期的Th1型细胞因子和慢性期的Th2型细胞因子可影响GO的发生和发展。
出处 《国外医学(内分泌学分册)》 2003年第6期401-402,共2页 Foreign Medical Sciences(Section of Endocrinology)
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