依那普利与硝苯地平控释片联用对高血压伴左室肥厚的疗效观察

THE CLINICAL EFFICACY OF COMBINATION THERAPY WITH ENALAPRIL AND NIFEDIPINE CONTROLLED ON THE ESSENTIAL HYPERTENSION WITH LEFT VENTRICULAR HYPERTROPHY

目的 :观察依那普利与硝苯地平控释片联用对原发性高血压 ( EH)伴左室肥厚 ( LVH)的疗效。方法 :将 EH伴 LVH患者 1 60例随机分为 A、B两组 ,A组 82例 ,单用依那普利 ,B组 78例 ,依那普利与硝苯地平控释片联用。观察两组在治疗前和治疗 6个月后及两组间血压与 LVH指标的变化。结果 :治疗 6个月后两组血压均较治疗前明显下降 ( P<0 .0 1 )且两组间降压幅度无显著性差异 ( P>0 .0 5 ) ;两组左室重量指数较治疗前均明显降低 ,A组 ( P>0 .0 5 )较 B组明显 ( P<0 .0 5 )。结论 :两药合用对

Objective:To observe the clinical efficacy of enalapril combined with nifedipine controlled for reducing left ventricular hypertrophy in patients with essential hypertension (EH).Methods:One hundred and sixty patients with EH were randomly divided into two groups,group A and group B.Group A served as enalapril treatment group (82 cases).Group B served as enalapril plus nifedipine controlled treatment group (78 cases).The indexes of observation included changes of blood pressure and left ventricular hypertrophy after 6 months treatment in both groups.Results:It was found that blood pressure was significantly decreased in both groups after 6 months treatment ( P <0 01),but no difference was found in the level of blood pressure reduction between the two groups( P >0 05).Index of left ventricular mass was reduced significantly in both groups( P <0 01) and this effect was more obvious in group B than in group A( P <0 05).Conclusion:Enalapril combined with nifedipine controlled may cause additive effect in the reduction of left ventricular hypertrophy.