摘要
目的 研究许旺细胞源神经营养因子对发育期运动神经元的效应。 方法 14只新生SD大鼠切断一侧面神经后随机分为实验组和对照组 ,实验组 ,局部用许旺细胞源神经营养因子 (10 μg/d) 1周 ,对照组予等量PBS。观察面神经核中运动神经元数量、形态。 结果 实验组运动神经元数量、形态均优于对照组。 结论 发育期面神经切断后 ,应用许旺细胞源神经营养因子可维持运动神经元存活。
Objective To study the neurotrophic activity of Schwann cells derived neurotrophic factor (SDNF) on developing motoneurons Methods The right facial nerve of 14 neonatal SD rats was transected neonatal SD rats was transected. The rats were randomly divided into two groups. SDNF (10μg/d) was applied for 7 days in experimental group and PBS(loul) was received in contral group. The mounts and morphology of motoneurons were studied. Results The number and morphometry of experimental group was better than that of controlled group significantly. Conclusion SDNF could save facial motoneurons fron axotomy induced cell death in neonatal rats.
出处
《中华显微外科杂志》
CSCD
北大核心
2003年第4期273-275,共3页
Chinese Journal of Microsurgery
基金
国家自然科学基金资助项目(39870 80 2)
