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细胞因子与多发性骨髓瘤的病理生理 被引量:3

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摘要 新近的研究表明,多种细胞因子参与了多发性骨髓瘤(MM)的病理生理机制。本文着重介绍了IL-1、TNF、LT等与MM溶骨病变、IL-4、B细胞生长抑制因子(BIF)与MM多克隆免疫球蛋白合成受抑、以及IL-6等细胞因子与骨髓瘤细胞恶性增殖之间关系的最新研究结果,存在的争议及有待解决的问题。对细胞因子与MM造血抑制的关系也扼要地作了介绍。
作者 侯健 孔宪涛
出处 《上海免疫学杂志》 CSCD 北大核心 1992年第2期123-125,共3页 Shanghai Journal of Immunology
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同被引文献10

  • 1侯健,黄隆安,纪徐淮,陈玉宝,王东星,屠小卿,孔宪涛.多发性骨髓瘤患者血清骨胶原代谢产物浓度与IL-6活性的相关性研究[J].中华血液学杂志,1996,17(11):569-571. 被引量:2
  • 2侯健,赵亚萍,刘焱,屠小卿,丁思奇,王东星,黄隆安,孔宪涛.浆细胞病患者血清可溶性白细胞介素-6受体检测及其临床意义[J].中华内科杂志,1997,36(2):94-96. 被引量:5
  • 3D. M. Nachbaur,M. Herold,A. Maneschg,H. Huber. Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters[J] 1991,Annals of Hematology(2-3):54~58
  • 4Thérèse Commes,Bernard Klein,Michel Jourdan,Gisèle Clofent,Frédéric Houssiau,Jean Grenier,Régis Bataille. The defect in peripheral blood B-cell activation in patients with multiple myeloma is not due to a deficiency in the production of B-cell growth and differentiation factors[J] 1989,Journal of Clinical Immunology(1):65~73
  • 5Tadamitsu Kishimoto. B-cell stimulatory factors (BSFs): Molecular structure, biological function, and regulation of expression[J] 1987,Journal of Clinical Immunology(5):343~355
  • 6D. M. Nachbaur,M. Herold,A. Maneschg,H. Huber. Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters[J] 1991,Annals of Hematology(2-3):54~58
  • 7Thérèse Commes,Bernard Klein,Michel Jourdan,Gisèle Clofent,Frédéric Houssiau,Jean Grenier,Régis Bataille. The defect in peripheral blood B-cell activation in patients with multiple myeloma is not due to a deficiency in the production of B-cell growth and differentiation factors[J] 1989,Journal of Clinical Immunology(1):65~73
  • 8Tadamitsu Kishimoto. B-cell stimulatory factors (BSFs): Molecular structure, biological function, and regulation of expression[J] 1987,Journal of Clinical Immunology(5):343~355
  • 9侯健,王东星,王永日,丁思奇,杨松山,梁之祥,孔宪涛.α和γ干扰素对骨髓瘤细胞白细胞介素6受体表达的调节[J].中国免疫学杂志,1998,14(3):195-197. 被引量:2
  • 10侯健,孔宪涛.多发性骨髓瘤发病相关机制研究[J].中华血液学杂志,1998,19(11):607-609. 被引量:5

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