米索前列醇对高危妊娠产后出血的预防作用

The Misoprostol's Preventive Effect on the Postpartum Hemorrhage of High-risk Pregnancy Women

目的 探讨米索前列醇 (米索 )对高危妊娠产妇产后出血的预防作用。方法 将高危妊娠 10 0例随机分为实验组及对照组 ,每组 5 0例 ,均为手术产妇 ,在剖宫取胎之后 ,实验组给产妇口服米索前列醇 4 0 0 μg ,宫体注射催产素 10u ;对照组 ,在剖宫取胎之后 ,立即宫体注射催产素 10u ,且静脉推注 2 0u ,观察两组产妇在胎儿娩出至产后 2h的出血量。结果 实验组产后 2h出血量 2 12 .5± 81.4ml,对照组 36 9.2± 10 7.8ml(P <0 .0 1)。结论 米索联合催产素促宫缩作用明显强于单用催产素 ,且米索口服给药方便 ,吸收迅速 ,兼有降低血压作用 ,尤其适应于妊高征患者 。

Objective To explore the preventive effect of misoprostol on postpartum hemorrhage.Methods 100 pregnant women were randomly divided into experimental and control group,each consisting of 50 cases.After delivery of cesarean section,the experimental group was orally given misoprostol 400μg and oxytocins 10u was injected into uterus body,while for the control group,oxytocins 10u was injected into uterus body immediately after delivery and 20u into vein.The hemorrhage amount within two hours was observed.Results The hemorrhage amount of experimental group within two hours was 212.5±81.4ml;the control group was 369.2±107.8ml.Conclusion The combining effect of misoprostol and oxytocins was stronger than oxytocins.Furthermore,misoprostol can be administered easily and absorbed swiftly as well as lower the blood pressure,making it especially suitable for the case of pregnancy induced hypertension syndrome.So the misoprostol is the ideal drug for promoting uterus contracting to high risk pregnant women.