孤独症儿童血浆5-羟色胺、出生季节和母孕期母亲情绪的初步探讨

Researching into the serotonin,Seasonality of births and mother's mood in the pregnancy of the childhood autism:A pilot study

目的 比较孤独症儿童和正常儿童血浆 5 羟色胺 (5 HT)浓度、出生季节和孕期母亲情绪 ,从而探索孤独症 5 HT增高的原因和可能的发病机制。方法 对 5 4名孤独症儿童和 5 5名正常儿童进行了血浆 5 HT检测、并调查出生季节、孕期母亲情绪。对孤独症儿童还进行了适应行为评定量表评定。结果 孤独症儿童适应行为评定量表的得分为 67.65± 1.67。孤独症儿童 5 HT浓度为 0 .78± 0 .3 2 μmol/L ;正常儿童 5 -HT浓度为 0 .62± 0 .16μmol/L ,两组经t检验有统计学差异显著性 (t =3 .17;P =0 .0 0 2 ) ,5 HT增高的孤独症儿童有 17人。与正常儿童比较 ,孤独症儿童冬春季出生居多 ,母孕期母亲情绪问题明显。结论 在胎儿神经发育的关键时期母体可能存在 5 HT系统功能增强 ,可能是导致孤独症 5 HT增高的原因 ,也许是孤独症可能的发病机制之一。

Objective To contrast the concentration of plasma serotonin,Seasonality of births and mother's mood in the pregnancy between children with autism and normal children. To probe into the cause of hyperserotonemia in the part of autism and the possibility of pathogeny of autism.Methods The concentration of plasma serotonin was examined , and investigating seasonality of births and mother's mood in the pregnancy among 54 children with autism and 55 normal children. The children with autism were evaluated by 'Scale of Function of Social Adapt'. Results The results of Scale of Function of Social Adapt rating in children with autism is 67.65±1.67. The concentration of plasma serotonin is 0.78±0.32 μmol/L in children with autism and 0.62±0.16μmol/L in normal children. The significantly difference of the concentration of plasma serotonin is found between children with autism and normal children by independent samples t test( t =3.17; P =0.002). There are 17 children with autism being hyperserotonemia. Contrasting normal children, the more children with autism is birth in season of winter and spring, and more distinctness mother's mood disorder in the pregnancy. Conclusion There may are phase of high-functioning of 5-HT in mother in key time of fetus cerebra development that may is one of causes of hyperserotonemia of autism, and that is possible one of etiologies of autism.