摘要
为探讨McAb激活T细胞,加强APC的递呈抗原的能力,采用CD28/CD80(受体与配体)McAb共激活的健康人的外周血淋巴细胞输入肿瘤患者,用FACS检测健康人、肿瘤患者治疗前后的PBLs的表型;结果显示在治疗前,肝癌患者PBLs有CD4偏移现象,而治疗后CD4偏移消失,CD3降低,且杀伤细胞(CD8+)增多。结论:通过共激活PBLs输入疗法,激活了T细胞某些被抑制了的功能,使不同的T细胞向相应细胞转化。
In this study, eleven cases of
hepatocellular carcinoma were treated by transfusion with McAb-costimulated PBLs from
healthy individuals. The phenotypes of PBLs from patients were analyzed by FACS before and
after the transfusion treatment. The results showed that there was a CD 4 cell bias in PBLs
from patients before treatment. After treatment, no CD 4 cells bias was found, the number of CD
8 cells increased, and the number of CD 3 cells decreased. The results suggested that McAb
costimulated T cell enhanced the capacity of APC.
出处
《广东药学院学报》
CAS
1999年第1期25-27,共3页
Academic Journal of Guangdong College of Pharmacy
基金
国家自然科学基金
广东省卫生厅基金