摘要
从中草药掌叶半夏(Pinellia pedatisecta Schott)中提取分离出的总蛋白成分,经化学分析证实,总蛋白中不含磷,不含脂蛋白,含有糖成分;经聚丙烯酰胺凝胶电泳(PAGE)分析,总蛋白中含有十余种蛋白质,蛋白质含量96.1％。动物实验显示,掌叶半夏总蛋白1％生理盐水液每天给每只小鼠腹腔注射0.1ml,对小鼠S-180瘤株的抑制率为50.1％～67.0％,平均为58.3％。经病理切片观察,实验组和对照组S-180瘤块细胞在细胞坏死数、核分裂数和细胞变性数三个指标上均有显著性差别。结果表明,掌叶半夏总蛋白对小鼠S-180癌细胞生长具有明显抑制作用。
Total protein obtained from the Chinese herb drug Pinellia pedatisecta Sohott by extraction with 0.9% NaCl and precipitated with acetone has been shown to possess antitumorio effects. The total protein constitutes 1% of the drug contains a sugar moiety but no phosphorus or lipoprotein. It exhibits marked antitumorio activity against mouse sareoma-180 by inhibiting growth of the sarcoma-180 tumor cells. The inhibiting ratio is 58.3%.
出处
《上海医科大学学报》
CSCD
1992年第1期17-20,共4页
Journal of Fudan University(Medical Science)
关键词
掌叶半夏
蛋白
抑瘤作用
Pinellia pedatisecta Sehott
protein
mouse sarcoma-180s antitumor activity
