摘要
采用全自动图像分析仪结合组化和免疫组化染色,对104例人肝穿刺材料中肝细胞和不典型增生肝细胞(LCD),组化γ-GT染色阳性细胞,免疫组化HBsA-g、HBcAg、AFP染色阳性细胞以及γ-GT染色阳性区域进行形态学定量研究。结果证实:重度慢性活动性肝炎(CAH)和LCD为肝癌的癌前病变,两者在肝细胞肝癌发生中有重要意义。
Human liver biopsy tissue were taken from 104 cases chronic persistent hepatitis (4), mild ohronio active hepatitis (14), moderate ohronio active hepatitis (43), severe chronic active hepatitis (29), normal liver tissue (10) and hepatooellular carcinoma (4). Two methods of study were: (1) histoohemical and immunohistochemical staining for r-GT, HBsAg, HBcAg and AFP; (2) morphometric measui-ements of normal hepatocytes, liver cells dysplasia, all histoohemioally and immunohistochemioally positive-staining cells, and r-GT positive-staining areas. The results showed: (1) very clear differences were found between chronic active hepatitis and normal liver tissue; and severe chronic active hepatitis was significantly correlated with hepatocarcinogenesis; (2) liver cells dysplasia might be considered a precarcinomatous lesion of hepatooellular carcinoma.
出处
《上海医科大学学报》
CSCD
1992年第1期33-36,共4页
Journal of Fudan University(Medical Science)
关键词
肝肿瘤
癌
原发性
病理
hepatocellular carcinoma
chronic hepatitis
liver cell dysplwia
premalignant lesion
morphometry
histochemistry
immunohistoohemistry
