摘要
复杂性状基因定位的研究是人类、动植物研究中的 1个热点领域。在畜禽的研究中 ,其目的是定位与生产性状、繁殖性状和疾病相关的基因。在人类中 ,复杂性状基因定位的研究具有极大的挑战性。尽管基因定位的结果积累得很快 ,但能得以确认的结果却很少。关于畜禽基因定位的研究结果同样也增长很快 ,目前在鸡、猪、奶牛等物种中几个大尺度的基因定位工作也正在开展中。虽然在不远的将来能够得到新的、可确信的结果 ,但是如何精确地理解这些复杂性状的基因仍然需要一定的时间。近来 ,复杂性状基因定位的方法已被用于通过基因表达的数据研究转录调节因子的定位工作中 ,这是基因定位研究中 1个新的领域。基因定位的统计分析和实验设计是基因定位研究中的关键性步骤 。
Gene mapping for complex traits has been an active and challenging research area in humans,agricultural and laboratory species.In domestic animals and poultry,the goal of gene mapping is to find genes associated with production,reproduction and health traits.In humans,gene mapping for complex diseases has been a significant challenge.Although gene mapping results are accumulating rapidly,confirmed results are scarce .In domestic animals,gene mapping results are also accumulating rapidly and several large scale mapping projects in chickens,swine,and dairy cattle are currently in progress.Although new and more reliable results can be expected in the near future,the precise understanding of genes underlying complex traits is still some distance away.Recently,the approach of mapping genes of complex traits has been applied to gene expression data to map transcription regulatory elements ,adding a new dimension to gene mapping.Statistical analysis of gene mapping data and experimental design are critical components of a gene mapping research.The purpose of this review article is to discuss current status as well as future directions and challenges in statistical analysis and experimental design for mapping genes of complex traits in domestic animals and poultry.
关键词
复杂性状
基因定位
家养动物
基因表达
complex trais
gene mapping
domestic animals
gene expression
