上海地区育龄期妇女、孕妇及其新生儿巨细胞病毒感染的调查

INVESTIGATION OF HUMAN CYTOMEGALOVIRUS INFECTION OF CHILDBEARING AGE WOMEN, PREGNANT WOMEN AND THEIR INFANTS

为调查上海地区人巨细胞病毒(HCMV)的感染情况,作者用间接酶联免疫吸附法(ELISA)检测1048份育龄期妇女、289对孕妇及其胎儿血清标本中HCMV特异性抗体。育龄期妇女HCMV-IgG阳性率为93.5％,<18岁、20～29岁和30～45岁组分别为54.9％、89.7％及95.4％,感染率随年龄增长而增加。HCMV感染与社会经济情况及婚姻状况有关。273份母血和266份脐血HCMV-IgG阳性,阳性率分别为94.46％和92.04％。HCMV-IgM阳性者母血13份,脐血10份,阳性率分别为4.49％和3.46％,表明产妇与其新生儿HCMV-IgM检出情况是密切相关的,胎儿可以从其HCMV-IgM阳性的母亲获得先天性感染。

In order to investigate the situation of human cytomegalovirus (HCMV) infection in Shanghai, we have detected the HCMV specific antibody in 1048 serum samples of child- bearing age women and 289 paired serum samples of mother and infant by indirect ELISA. The positive rate of HCMV-IgG of childbearing age women was 93.5%. The positive rates of HCMV-IgG in<18, 20-29 and 30-45 years of age were 54.9%, 89.7% and 95.5% respectively. It suggests that the HCMV infection increases with age. In addition, we also found that HCMV infection is related to the status of socioeconomy and marriage. Two hundred seventy-three maternal serum samples and 266 umbilical cord serum samples were positive for HCMV-IgG, with positive rates of 94.46% and 92.04% respectively. While 13 maternal serum samples and 10 umbilical cord serum samples were positive for HCMV-IgM, with positive rates of 4.49% and 3.46% respectively. The close relation of HCMV-IgM levels between mothers and their babies indicated that infants might acquire congenital infection from their mothers with positive HCMV-IgM.