病毒性肝炎患者纤溶活性变化的研究

ALTERATION IN PLASMA FIBRINOLYTIC ACTIVITY IN PATIENTS WITH VIRAL HEPATITIS

用组织纤溶酶原激活物(t-PA)、纤溶酶原抗原(PLG:Ag)和活性(PLG:A)、纤溶酶(PL)、纤维蛋白(原)降解产物(FDPs)、纤溶酶原激活抑制物(PAIs)和α_2-纤溶酶抑制物(α_2-PI)为指标,研究70例正常人和231例各型病毒性肝炎的纤溶活性的变化。结果表明,患者的t-PA升高,PAIs减低,PLG减少,PL升高,α_2-PI减低,FDPs升高。揭示在排除弥漫性血管内凝血(DIC)的情况下,肝炎患者的纤溶活性是增强的,系原发性纤溶。此为肝炎出血提供理论依据。本研究发现交叉反应物质阳性(CRM^+)的PLG、FDPs是反映纤溶活性的简便和实用的指标。

Plasma concentrations of t-PA, PLGAg, PLGA, PL, FDPs, PAI and α_2-PI wers assessed in 70 normal subjects and 231 patients with various types of viral hepatitis, They were used as indicators of plasma fibrinolytic activity. In patients with viral hepatitis, the plasma levels of t-PA, PL and FDPs increased, but the plasma levels of PAI, PLG and α_2-PI decreased, suggesting an augmentation of plasma fibrinolytic activity. This may provide an important theoretic basis of hemorrhage in these patients. Determination of plasma levels of CRM^+ PLG and FDPs may be a simple and practical method in the evaluation of plasma fibrinolytic activity in patients with viral hepatitis.