摘要
应用放射免疫测定法(RIA)和放射受体测定法(RRA)同时测定糖尿病患者空腹血清胰岛素时,发现有2例结果差异极大。用前法的血清胰岛素为22μU/ml和17μU/ml(均属正常),用后法为2700μU/ml和2432μU/ml。从2例血清中提取IgG,用人红细胞和豚鼠肝膜与胰岛素受体制剂进行实验,表明均能抑制^(125)I-胰岛素与胰岛素受体的结合,其抑制能力是正常人血清IgG的百倍以上,提示可能为抗胰岛素受体的自身抗体(AIRA)。
Great difference in serum insulin concentrations by radioimmunoassay (RIA) and radio- receptorassay (RRA) was discovered in two diabetes mellitus cases. They were 22 μU/ml and 17μU/ml by RIA, but were 2700μU/ml and 2432μU/ml by RRA respectively. The IgG pre- pared from the sera of the two patients could inhibit insulin binding to its receptor. Their potencies were more than 100 times that of IgG from normal donor, suggesting the presence of anti-insulin receptor autoantibodies.
出处
《上海医学》
CAS
CSCD
北大核心
1992年第7期388-391,共4页
Shanghai Medical Journal
关键词
糖尿病
AIRA
Diabetes mellitus
anti-insulin receptor autoantibody
