脑膜瘤生物学特性的研究——流式细胞计对脑膜瘤DNA含量的分析及其生物学行为的相关研究

FLOW CYTOMETRY OF DEOXYRIBONUCLEIC ACID IN MENINGIOMA:A CORRELATIVE STUDY OF THEIR BIOLOGICAL BEHAVIOR

为了定量测试脑膜瘤WHO分级法的价值,作者应用倍体分类、增殖指数和S期细胞比率三项参数进行分析,发现这三项指标与WHO分级密切相关。脑膜瘤异形细胞、坏死、核分裂及脑浸润的出现与肿瘤WHO分级增加和肿瘤复发密切相关。这些结果特别对肿瘤的异质性和测量技术差异问题给予小心评价。

In order to quantitate and test the value of the WHO scale of grading tumors of meninges, we applied DNA FCM analysis of meningioma. The following parameters were used: degree of ploidy, proliferative index and the S phase DNA percentage. These parameters were significantly intercorrelated and were in correlation with the WHO scale of grading system and its criteria such as mitosis polymorphism, necrosis and brain invasion were found to be significantly correlated to the degree of tumor malignancy and tumor recurrence.