子宫肌瘤与雌、孕激素及其受体关系的探讨

ESTRADIOL, PROGESTERONE AND THEIR RECEPTORS CONCENTRATIONS IN HUMAN UTERINE LEIOMYOMA

对32例子宫肌瘤及同一子宫内膜、肌层组织胞浆、胞核的雌二醇和孕酮受体含量以及这些组织中雌二醇和孕酮含量进行了测定。胞浆受体含量与肌瘤细胞多少成正比。胞核受体含量与胞核活跃程度成正比。将肌瘤细胞数量对胞浆受体含量及将胞核活跃程度对胞核受体含量分别作校正后得出:肌瘤组织雌、孕激素含量及胞浆、胞核受体含量均显著高于同一子宫肌层中的含量(P<0.05～0.005)。提示子宫肌瘤组织的变性可影响受体含量的测定。子宫肌瘤的发生、发展与子宫局部雌、孕激素及其受体含量可能有其相关性。

Uterine leiomyomas of thirty-two patients were studied through determinations of E_2R and PR concentrations in cytosol and nucleus of the endometrium, myometrium and myoma tissues of the same uterus by radioreceptorassay. At the same time, estradiol and progesterone of all these tissues in each patient were also measured by radioimmunoassy. The results revealed that the concentrations of E_2R and PR in cytosol and nucleus of tumor cells were in direct proportion to the amount of myoma cells and their nuclear activity. After correction of cytosol receptor for tumor cell count and nuclear receptor for nucleus activity, the concentrations of E_2R and PR in cytosol and nucleus of myoma tissue were found higher than those in the uterine muscular layer of the same uterus (P<0.05). This study demonstrates: (1) receptor concentrations were influenced by degeneration of uterine leiomyoma; (2) variation in receptor concentrations of myoma due to degeneration may be corrected through gradation of cell count and nuclear activity of myoma cells; and (3) the pathogenesis of uterine leiomyoma is possibly related to high local concentrations of E and P as welt as their receptors in the uterus.