尼莫地平对缺血性脑损害的实验研究

EXPERIMENTAL STUDY ON BRAIN ISCHEMIC DAMAGE

本文将51只雄性Wistar大鼠随机分成假手术对照组、缺血组、缺血-尼莫地平组。采用改良Pulsinelli法建立鼠脑缺血模型,并经脑电图监测及组织病理学检查证实缺血模型是成功的。缺血-尼莫地平组的大鼠在夹闭颈总动脉造成鼠脑暂时性缺血的同时於腹腔内注射尼莫地平。比较对照组及暂时性缺血再灌注72小时后海马组织钙含量,用原子吸收分光光度计测定发现缺血组海马组织钙含量增高,但缺血-尼莫地平组海马组织钙含量与缺血组差异无显著性。

Using a modified method of Pulsinelli's induction of brain ischemic damage in wistar rat by 4-vessel occlusion, calcium content in hippocampus was found significantly higher in ischemic group. Nimodipine (1 mg/kg) was injected intraperitoneally following brain ischemia, the calcium content in hippocampus had no significant difference between Nimodipine treated group and ischemic group.