常量卡维地洛对急性心肌梗死近期左心室功能的影响

Effect of common-dose Carvedilol on recent left ventricular function of patients with acute myocardial infarction

目的 用超声心动图评价常量卡维地洛对急性心肌梗死后近期左心室功能的影响。方法 74例急性心肌梗死患者 ,在用药前、用药 6个月后进行超声心动图检查。用修改的Simpson法经心尖四腔和二腔切面测定左心室收缩末容量、舒张末期容量和左室射血分数。结果 卡维地洛组心率比安慰剂组减慢 ,而安慰剂组左心室舒张末期容量和收缩末期容量增加 ,卡维地洛组容量减少。卡维地洛组左心室舒张末期容量指数比安慰剂组显著减少 (t =2 .470 ,P <0 .0 5 ) ;左心室收缩末期容量指数明显减少 (t =2 .6 86 ,P <0 .0 1) ,左心室射血分数增加 (t =2 .5 45 ,P<0 .0 5 )。结论 常量卡维地洛治疗急性心肌梗死 6个月 ,减少左心室容量 ,增加LVEF。

Objective To study the effect of common-dose carvedilol on recent left ventricular function of patients with acute myocardial infarction by the quantitative two-dimensional echocardiography.Methods Seventy-eight patients with acute myocardial infarction were enrolled into the study.Echocardiography was performed before treatment and was repeated after 6 months of treatment.Left ventricular end-diastolic,end-systolic volumes and left ventricular ejection fraction were measured from apical four-and two-chamber views with the use of a modified Simpson rule method.Results After 6 months,heart rate was lowered in the carvedilol than in the placebo group,whereas left ventricular end-diastolic and end-systolic volumes were increased in the placebo group but reduced in the carvedilol group.At 6 months,left ventricular end-diastolic volume index was significantly less in the carvedilol than in the placebo group (t= 2.470,P< 0.05),left end-diastolic volume index was obviously less (t= 2.686,P< 0.01),and left ventricular ejection fraction was greater (t= 2.545,P< 0.05).Conclusion In patients with recent myocardial infarction,carvedilol therapy for 6 months reduced left ventricular volumes,increased left ventricular ejection fraction and prevented progression of left ventricular dilation.These changes showed a beneficial effect of carvedilol on recent left remodeling.