硫普罗宁治疗慢性乙型病毒性肝炎的临床观察

Observation of the curative effect of tiopronin on chronic hepatitis B

目的 :评价硫普罗宁在治疗慢性乙肝型病毒性肝炎中的降酶、退黄等保肝作用。方法 :83例慢性乙型病毒性肝炎患者分为治疗组 (43例 ) ,用硫普罗宁治疗 :对照组 (40例 )用易善复治疗。治疗前后观察血清转氨酶 (ALT、AST)、白蛋白 (ALB)、胆红素(TBIL、DBIL)及乙型肝炎病毒标志物 (HBVM)的变化。结果 :治疗组降低转氨酶有效率为76 7%～79 1%、退黄有效率为69 8%与对照组相比较两组差异无显著性 (P>0 05) ,其中治疗组降AST与对照组相比较差异有显著性 (P<0 05)。HBsAg、HBeAg、HBVDNA阴转率与对照组比较差异无显著性(P>0 05)。结论 :硫普罗宁是具有明显降低血清转氨酶 (尤其对AST和胆红素作用的保肝药物 ,但对病毒复制无影响。

Objective:To assess the curative effect of tiopronin on the degradation of transaminase and the reduction of hepatogenous jaundice during the cure of chronic viral hepatitis B,and its other related anti-virus effects.Methods:83cases with chronic viral hepatitis B were divided into two groups:the therapeutic group(43cases)were treated with tiopronin for injection;while the comparision group(40cases)were treated with essential for injection.The levels of ALT,AST,TB and HBVMwere monitored,before and after the period of treatment.Results:In the therapeutic group,the reduction rate of transaminase was76.7%～79.1%,and the reduction rate of hepatogenous jaundice was69.8%;while the compariˉsion group,the reduction rate of transaminase was77.5%～79.1%,and the reduction rate of hepatogenous jaundice was75.0%.Eventhough no significant difference(P>0.05)was observed on these aspects.Yet the degradation rate of ASTin the therapeutic group was much higher than that in the comparision group and there was remarkable difference between them(P<0.05).The rates to turn negative on HBsAg,HBeAg,HBV DNA were lowin both group,and no significant difference was observed(P>0.05).Conclusion:Tiopronin is a hepatoprotection drug,which has sigˉnificant effect on reduction of serum transaminase and bilirubin,but has no effect on virus reproduction.