自发性脑干出血患者血浆维生素C及相关抗氧化剂浓度变化

Changes of plasma vitamin C and relative antioxitant levels in patients with spontaneous cerebral-stem hemorrhage

目的 探讨自发性脑干出血患者抗氧化剂耗竭发生的时间与临床危重程度的关系。方法 对 2 7例自发性脑干出血患者发病 2 4h、7d、2 8d血浆维生素C、维生素E、尿酸、辅酶Q10 浓度进行测定 ,与健康人群相比较。并按出血量大小分A、B、C三组 ,比较各组间抗氧化剂浓度的变化。结果 脑干出血组各项指标均低于健康人群 (P <0 0 1) ,以发病 2 4h内最低 ,以出血量 >4ml降低最明显。结论 自发性脑干出血患者存在明显的抗氧化剂消耗 ,并与临床危重程度呈负相关。

Objective To discuss the relation between antioxidant depletion in patients with spontaneous cerebral-stem hemorrhage(SCSH)and the degree of clinical severity. Methods We measured plasma levels of vitamin C,vitamin E,uric acid(UA),and ubiquino1-10 at 24h,7d,28d in 27 patients with SCAH and compared with the normal healthy control.Divided patients into three groups according to the volume of bleeding,and observed the alteration of antioxidant.Results SCSH patients had significantly lower plasma levels of vitamin C,vitamin E,UA,and ubiquino1-10 compared with healthy subjects (P<0.01),the lowest level at 24h latter bleeding,and dreased obviously occurred volume of bleeding more than 4ml.Conclusion There is antioxidant depletion occure in patients with SCSH,and has negative relative with clinical severity degree.