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吡啶酮类抗菌候选药物ABT-719与A-170568

The potent candidates of pyridone antibacterial agents ABT - 719 and A - 170568
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摘要 吡啶酮类化合物ABT—719和A—170568具有抗菌谱广、抗耐药菌活性强、毒性低等特点。综述这2个候选药物的化学结构、作用机制、抗菌活性、体内安全性等药理学性质。 ABT- 719 and A- 170568,two compounds of 2-pyridone antibacterial agents,have potent antimicrobial activity and low toxicity,and may be improved to two potent drugs of combatting the resistance to quinolones. In this article,the two candidates'chemical structure,mechanism of action and pharmacological properties were reviewed.
作者 郑忠辉 金洁 刘浚 武燕彬
机构地区 中国医学科学院中国协和医科大学医药生物技术研究所
出处 《中国新药杂志》 CAS CSCD 北大核心 2003年第9期691-694,共4页 Chinese Journal of New Drugs
关键词 吡啶酮 抗菌活性 喹诺酮 ABT-719 A-170568 pyridone antibacterial activity quinolone ABT- 719 A - 170568
分类号 R978 [医药卫生—药品]
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参考文献11

  • 1Shen LL,Chu DTW. Type Ⅱ DNA Topoisomerases as Antibacterial Targets[J]. Curr Pharm Des, 1996,2(2) : 195 - 208.
  • 2Li Q,Claihorne A, Chu DWT, et al. 2-Pyridones emerging as most potent novel class of antimicrobial agents: synthesis and antibacterial activity of A - 86719. 1 and related 2-pyridones, A novel series of potent DNA gyrase inhibitors[ A]. 35th Interscience Conference on Antimicrobial agents and chemotherapy [ C ]. Washington DC: American Society for Microbiology ,1995,F8.
  • 3Li Q,Sowin T,Claiborne A, et al. Practical Synthesis of 2-Pyridone Core: ethyl-8-chloro-l-cyclopropyl-7-fluoro-9-methyl-4-xo-4H-quinolizinone-3-carboxylate[ J ]. Hereocycles, 1999,51 ( 6 ) : 1347 - 1353.
  • 4Elopoulos GM,Wennetsten CB,Cole G, et al. In Vitro activity of A- 86719.1, a novel 2-pyridone antimierobialAgent [ J ]. Antimicrob Agents Chemother, 1995,39( 4 ) : 850 - 853.
  • 5Flamm RK, Vojtko C, Chu DTW, et al. In Vitro evaluation of ABT - 719, a novel DNA gyrase inhibitor [ J ]. Antimicrob A-gents Chemother, 1995,4:964 - 970.
  • 6Alder J, Clement J, Meulbroek J, et al. Efficaeies of ABT - 719 and related 2-pyridones,members of a new class of antibacterial agents, against experimental bacterial infections [ J ]. Antimicrob Agents Chemother, 1995,39 (4) : 971 - 975.
  • 7Armiger YL,Chu DTW,Fung AKL, et al. The discovery of A-165753 and A - 170568. 1[A]. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy[C] . Washington DC: American Society for Microbiology, 1998. F86.
  • 8Meulbroek J,Jarvas K, Mitten M, et al. Efficacies of A- 170568.1 a pyridone antibacterial agents, against experimental bacterial infections [ A]. 38th lnterscience Conference on Antimicrobial Agents and Chemtherapy [ C ]. Washington DC: American Society for Microbiology, 1998. F81.
  • 9Jones RN, Marshl SA, Pfaller MA, et al. Nosocomial enterococcal blood stream infections in the scope program: matimicrobial resistance, species occurence, molecular testing results, and laboratory testing accuracy[J]. Diagn Microbial Infect Dis ,1997,28:95 - 102.
  • 10Anthony K,Fung L, Shen LL. The 2-Pyridone Antibacterial Agents:8-Position Modifications[J]. Curr Pharm Des, 2001,15 (8):515- 543.
中国新药杂志
2003年 第9期

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