摘要
综述新型抗菌药物噁唑烷酮类化合物近几年来的构效关系研究新进展,重点讨论母环上3位和5位的结构改造,噁唑烷酮3位氮原子接一苯环,苯环的对位为杂环取代,5位为乙酰胺甲基、硫代乙酰胺甲基、异噁唑氧甲基等,这些改造所得的化合物大都有良好的抗G^+菌活性。
In this paper, new development in structure-activity relationship research of oxazo-lidinone antibiotics was reviewed. The key point discussed is the modification of substituents in posi-tions 3 and 5 on oxazolidinone ring. If there is a phenyl group,or a p-heterocyclic phenyl group in posi-tion 3,and an acetamidomethyl,a thioacetamido- methyl,or a isoxazoloxymethyl group in position 5, then the resultant derivatives would possess good antibacterial activity against G+ bacteria.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2003年第9期694-700,共7页
Chinese Journal of New Drugs
关键词
噁唑烷酮
构效关系
抗菌药物
oxazolidinone
structure-activity relationship
antibacterial
