低张胶体液对失血并腹腔海水浸泡伤实验犬的救治作用

Effect of hypotonic liquid containing colloid on hemorrhagic dogs with celiac seawater immersion wound

目的 :观察低张胶体液对失血并腹腔海水浸泡伤的救治效果。方法 :建立腹腔海水浸泡伤动物模型。35只犬随机均分为对照组 (A组 )、质量分数为 5 %的葡萄糖治疗组 (B组 )、0 .4 5 %氯化钠治疗组 (C组 )、0 .9%氯化钠治疗组 (D组 )及低张胶体液治疗组 (E组 ) ,观察每组动物腹腔海水浸泡后平均动脉压 (MAP)、心排血量 (CO)、尿量、血浆渗透压及脑、肺组织的病理学变化。结果 :低张胶体液可显著改善 MAP及 CO,增加尿量 ,降低血浆渗透压 ,预防脑、肺水肿的发生。结论 :低张胶体液对失血并腹腔海水浸泡伤具有较好的救治效果。

Objective: To determine hypotonic liquid containing colloid on hemorrhagic dogs with celiac seawater immersion wound. Methods: Thirty-five dogs were randomly divided into five groups: control group(group A), 0.9%NaCl therapy group(group B) and 0.45%NaCl therapy group (group C), 5% glucose therapy group(group D) and hypotonic liquid containing colloid therapy group(group E). Changes of mean artery pressure(MAP), cardiac output(CO), urine volume, plasma osmotic pressure and pathologic changes of lung and brain were observed. Results: hypotonic liquid containing colloid could effectively ameliorate MAP and CO, improve urine volume, decrease plasma osmotic pressure and prevent occurrence of lung and brain edema. Conclusion: Hypotonic liquid containing colloid can exert satisfactory therapeutic effects on hemorrhagic dogs with celiac seawater immersion wound.