肺部孤立性结节定量研究

Quantitative Study of Pulmonary Isolated Nodules

目的 研究肺部孤立性结节形态参数在良恶性鉴别诊断中的应用价值。方法 选择了在 2 0 0 0年 4月至 2 0 0 1年 5月间 ,经CT引导下肺穿刺活检的 ,且经病理证实的良恶性患者 87例 ,其中良性 18例 ,恶性 69例。对这些病例按三个步骤进行分析 :首先 ,应用Snake模型提取结节的轮廓线 ;然后 ,计算由轮廓线所围成的区域的Legendre矩和傅立叶描述子(FD) ,并求出平均值 ,最后 ,对测量结果 ,利用SAS软件包进行t检验计算机统计学处理。结果 经过t检验 ,矩和傅立叶描述子两个形态学参数在良恶性肿瘤之间具有显著性意义。恶性肿瘤的矩值大于良性肿瘤 ,而FD值恰恰相反。应用矩、傅立叶描述子的 2者组合鉴别肺部孤立性结节良恶性肿瘤具有较高的诊断价值。结论 矩和傅立叶描述子能够定量描述肺部结节的形态特征。

Objective To assess the diagnostic value of shape parameters between benign and malignant in pulmonary isolated nodules. Methods All the 87 cases (18 benign, 69 malignant) were confirmed by pathology. The analysis of these cases was performed in three stages: First, Snake model was used to obtain lesion's boundary. Then, two measures of shape features, including moment and Fourier descriptors (FD), were computed for each region,and their average value was calculated. Finally, the t test was used for all results' statistical analysis by SAS software bag. Results The difference in either moment or FD between malignant and benign had remarkable significance. The value of moment malignant was larger than that of benign, and FD was contrary to moment. Using combination of shape features, the malignant could be predicted. Conclusion Moment and FD can describe quantitatively shape features of pulmonary nodule. [