心先安治疗慢性肺心病心肺功能不全的临床研究

EFFECTS OF MEGLMINE CYCLIC ADENYLATE ON CHRONIC COR PULMONALE WITH RESPIRATORY AND HEART INSUFFICIENCY

目的 观察环磷酸腺苷葡甲胺 (心先安 )治疗慢性肺心病心肺功能不全的临床疗效。方法 将 89例慢性肺心病患者分为观察组 (48例 )和对照组 (41例 ) ,两组常规治疗相同 ,观察组加用心先安注射液 ,疗程 7～ 10d。比较两组治疗后临床症状、体征、心功能指标、肺通气功能和动脉血气的改善程度。结果 观察组和对照组的临床症状和体征改善的有效率分别为 91.7%和 73 .1% ;肺活量 (VC)较治疗前分别增加 (43 1± 119)ml和 (3 0 7± 13 6)ml ;1秒钟用力呼气量 (FEV1)分别增加 (2 59± 49)ml和 (189± 51)ml ;最大呼气流量 (PEF)分别增加 (0 .73± 0 .3 1)L/s和 (0 .42± 0 .2 9)L/s;动脉血氧分压 (PaO2 )分别增加 (2 5.1± 8.9)mmHg和 (16.3± 10 .1)mmHg ,心功能指标改善程度 ,观察组优于对照组 ,两组比较差异有非常显著性 (P <0 .0 5)。

Objective\ To observe the clinical effects of meglumine cyclic adenylate (MCA) in treating the patients of chronic cor pulmonale with respiratory and heart insufficiency. Methods\ 89 patients with chronic cor pulmonale were divided into two groups: MCA group and control group. Both groups of patients were treated with the same ordinary methods, but MCA was given in the MCA group. The period of treatment was 7～10 days. The degree of improvement in clinical symptoms, signs, cardiac function index, pulmonary ventilation function and arterial blood gas analysis of the two groups before and after treatment were compared. Results\ The rates of improvement in clinical symptoms and signs were 91.7% and 73.1% in MCA group and control group respectively. VC increased (431±119) ml and (307±136) ml respectively as compared with the values before the treatment. FEV 1 increased (259±49) ml and (189±51) ml, PEF increased (0.73±0.31) L/s and (0.42±0.29) L/s,PaO 2 increased (25.1±8.9) mmHg and (16.3±10.1) mmHg respectively. The degree of improvement in the cardiac function index of MCA group was greater than that of control group and there was significant difference between the two groups (P<0.05).Conclusion\ Significant therapeutic effects were obtained in treating patients of chronic cor pulmonale with respiratory and heart insufficiency by using ordinary treatment measures combined with MCA injection.