抑郁症患者威斯康星卡片分类测验和连续操作测验的初步研究

Wisconsin Card Sorting Test and Continue Performance Test in Depression

目的 :通过与精神分裂症患者和正常对照的比较 ,探讨抑郁症患者的执行功能和注意功能。方法 :采用威斯康星卡片分类测验 (WCST)、连续操作测验 (CPT) ,对 66例精神分裂症患者、 42例抑郁症患者和 5 0名对照者的执行功能和注意功能进行评估。结果 :两组患者WCST中的总测验次数、持续错误数和随机错误数均明显多于对照组 (P <0 0 1) ;其中精神分裂症组WCST的三项成绩明显差于抑郁症组 (P <0 0 1) ;无干扰刺激时 ,精神分裂症组的认对数明显差于抑郁症组和对照组 (P <0 0 1) ,而抑郁症组与对照组之间的差异无显著性 (P >0 0 5 ) ;有干扰刺激时 ,精神分裂症组与对照组的差异有显著性 (P <0 0 1) ,抑郁症组与其它两组的差异均无显著性 (P >0 0 5 )。结论 :抑郁症组有执行功能障碍 ,介于精神分裂症组和对照组之间 ;在抑郁症组中没有发现有明显的注意障碍。

Objective: To study the executive and attention function of patients with depression. Methods: We used the Wisconsin Card Sorting Test (WCST) and Continue Performance Test (CPT) to study the executive and attention function in 66 patients with schizophrenia, 42 patients suffering from depression, and 50 normal controls. Results: Schizophrenic patients and depressive patients performed worse than the normal controls in WCST (P<0.01). Compared with the comparison group, schizophrenic patients but not depressive patients have impaired CPT in have or no interfere stimulus (P<0.01). Conclusions: Patients with schizophrenia had both attention and working memory/executive function impairment, patients with depression had the executive dysfunction.