老年人单核/巨噬细胞吞噬功能及一氧化氮产生能力的改变

The changes of phagocytosis and production of nitric oxide of monocyte/macrophage in the elderly

目的 探讨老年人单核巨噬细胞免疫功能的变化。方法 比较老年组与对照组外周血单核巨噬细胞吞噬功能及一氧化氮 ( NO)产生能力的变化。结果 老年组与对照组单核巨噬细胞吞噬百分率分别为 ( 37.2± 3.2 ) %、( 59.1± 4 .7) % ,吞噬指数分别为 0 .6 0± 0 .0 8和 1 .0 7± 0 .0 9;细菌脂多糖 ( L PS)刺激前后细胞培养上清中 NO的浓度老年组为 9.7± 1 .0μmol/L与 2 5.1± 6 .1μmol/L ;对照组为 1 6 .9± 1 .1μmol/L与 4 8.5±6 .7μmol/L。老年组均低于对照组。结论 老年人单核巨噬细胞免疫功能减退 ,提高老年人单核巨噬细胞吞噬功能及

Objective To investigate the change of phagocytosis and production of nitric oxide of mono cyte/macrophage in the elderly.Methods The phagocytic rat e , phagocytic index and the nitric oxide production in the elderly were compare d with that in the young control group.Results The phagoc ytic rate , phagocytic index and the nitric oxide production in the elderly were lower than that in the young control group .Conclusions The immune function of monocyte/macrophage is decreased in the elderly. Therefor e, improving the phagocytosis and production of nitric oxide of monocyte/macroph age in the elderly may be a new immune adjustment treatment.