住院肺结核病人对氧氟沙星耐药情况分析

The Resistance of ofloxacin(OFLX) in Hospitalized Patients with Pulmonary Tuberclosis

目的 了解住院肺结核病人对氧氟沙星的耐药性 ,从而探讨氧氟沙星作为耐多药结核病首选药物的可行性。 方法 对 2 0 0 0年 3月～ 2 0 0 2年 12月期间的住院肺结核病人有抗结核药物敏感试验结果者 14 0例进行氧氟沙星耐药性的回顾性调查。 结果 曾使用氟喹诺酮类药物者治疗者 2 3例中 ,8例对 OFL X耐药 ,继发耐药率为 34.78% ;既往从未使用过氟喹诺酮类药物 117例中 ,15例耐药 ,原发耐药率为 12 .82 %。 结论 随着临床上越来越多的使用氟喹诺酮类药物 ,氧氟沙星耐药率有所增高 ,但相对其他的抗结核药物 ,氧氟沙星的耐药率较低 ,仍可作为临床上一个有效的抗结核药物 ,用于耐多药结核病的治疗是可行的谭云洪 (1 970— ) ,女 ,湖南茶陵人 ,主管技师 。

Objective Analyse the resistance of OFLX of in patients with pulmonary tuberculosis to study the feasibility of OFLX that chosen as the first drug to MDR-TB. Methods Retrospectively investigate 140 cases with pulmonary tuberculosis that were sputum culture-positive and possessed drug susceptibility test results from Mar.2000 to Dec.2002. Result The result showed that 8 cases (34.78%)occurred secondary resistance,15cases (12.82%) occurred primary resistance.It is suggested that long term use of anti-TB drug and equivalent to monotherapy with OFLX are the causes of secondary resistance, and infected by OFLX-resistant bacilli or having been used to cure common inflammation may lead to primary resistant. Conclusion Due to it's low resistance rate, OFLX is still an effective anti-tuberculosis drug,though the rate increases lightly.It is feasible to choose OFLX as the first drug to MDR-TB.