尿微量蛋白在重型脑伤中对肾脏损害的临床意义

The predictive value of uromicroprotein detection for early kidney lesion in patients with severe brain injury

目的 探讨尿微量蛋白检测对诊断重型脑伤患者早期肾损害的临床意义。方法 采用免疫速率散射比浊法 ,检测 80例重型脑伤和 80例轻型脑伤患者尿液α1 -微球蛋白 (α1 - M)、微量白蛋白 (MA)、转铁蛋白 (TRF)和免疫球蛋白 G(Ig G)的含量 ,同时酶速率法测定患者血尿素氮 BUN) ,Jaffe速率法测定血肌酐 (Cr)。结果 重型脑伤患者尿α1 - M、MA、TRF、Ig G,血 BUN、Cr的含量比轻型脑伤患者增高 (P<0 .0 1)。脑伤患者尿α1 - M、TRF与血 BUN呈正相关。结论 重型脑伤患者确实存在不同程度的肾损害。尿α1 - M、MA、TRF和 Ig G是诊断肾脏早期损伤灵敏。

Objective To investigate the signiticance of detection of uromicroprotein in diagnosis of early kidney lesioin in severely head injured patients.Methods The concnetration of urinary α 1 microglobulin(α 1 M), microalbumin(MA), transferring(TRF) and immunoglobulin G(IgG) were measured by rate nephelometry in 80 patients with severe head injury and 80 patients with mild head injury. Simultaneously blood urea nitrogen(BUN) was determined with kinetic rate assay and serum creatinine(Cr) was determined with Jaffe's rate in all patients.Results Urinary α 1 M,MA,TRF and IgG concentrations in severe head injury group were significantly higher than those in mild head injury group. The levels of urinary α 1 M and TRF were significantly correlated with.Conclusions The renal damage really existdetecfionses of in patients with severe head injury. The urinary α 1 M, MA, TRF and IgG are sensitive and reliable for the diagnosis of early renal damage.