用中医理论指导中药及复方研究

Study of Chinese Herbs and Its Compound Prescription Guided by Traditional Chinese Medical Theory

医药结合 ,强化中医理论指导下的中药研究与应用 ,加快创新体系建设 ,成为新时期中医药研究中的关键问题。本文认为 ,在复方研究中 ,应依据中医临床要求 ,结合现代实验方法建立动物模型。复方研究需从药效学观察及临床疗效分析中找到突破口。复方药动学研究应注重方法学研究和有效物质的确定。由于复方的疗效在不同的证状态下作用不同甚或相反 ,重视中药复方行为有效性的主体———中医证候同样重要。多元化的中药研究思路从不同角度对中医药学术的发展进行了积极的探索 ,中药研发及方证对应理论体系构建的目的在于建立治疗临床疾病的新型高效中药的组方优化理论和设计方法学及方证对应的规范标准及用药监测 ,从而在中药及复方临床实验中建立新型中药临床使用标准 。

It is the key problem of TCM study in the new times to strengthen th e research and application of Chinese herbs and its compound prescription direct ed by TCM theory by combining medicine and drugs, accelerating the creation and construction of modern the new system. In the study of compound, animal mode sho uld be set up by the combination of modern experimental method according to TCM clinical requirements. A breakthrough in compound prescription needs to be found out from observation of pharmacodynamics and analysis of clinical therapy. Meth odology and clarification of effective materials should be paid enough attention to in study the pharmacokinetics of the compounds. Since the therapeutic effect s of compound prescriptions are different, or even opposite to itself under diff erent Syndromes, it is so important to pay attention to Syndrome Differention. M ultiple ways of TCM study have given active exploration on the developing of TCM academic level from different aspects. The aim of constructing a system of deve loping TCM and Syndrome-corresponding compound prescription is to build up a no rmalized standard of new and highly effective theory in treating diseases clinic ally, designing methodology, Syndrome-corresponding prescription and monitor th e compound prescription used. In this way, a new TCM clinical standard could be set up in Chinese medicine and its compound prescription in clinical experiments to raise the medical level continuously.