人参皂苷保护脊髓神经元与NO的关系

The Relationship Between the Protection of Ginsenoside for Spinal Cell and Nitric Oxide

目的 :探讨人参皂苷保护脊髓神经元与一氧化氮 (NO )的关系。方法 :体外培养鼠胚脊髓神经细胞 ,划痕法建立周围神经损伤模型 ,用Griess法间接测定NO含量。结果 :损伤组的NO含量比非损伤组高 ,损伤时人参皂苷培养组的NO含量比常规培养基组的含量低。结论 :周围神经损伤时NO含量增高 。

Objective: To study the relationship betwe en the protection of Ginsenoside(GS) for spinal cells and nitric oxide(NO). Method: Spinal cells were cultured in vitro, the model of perip heral nerve was established by scarifying the cells, and NO was measured by Grie ss method. Result: NO in injury group was high than that i n noninjury group and NO in group cultured by GS was less than that in group cul tured by common medium. Conclution: NO increases when peri pheral nerve is injuried, and the protective effect of GS on spinal cells may be through inhibiting NO release.