前列腺特异性抗原的检测对前列腺癌及前列腺增生的诊断意义

The Significance of Detection of Prostate Specific Antigen in the Diagnosis of Prostate Tumor and Benign Prostate Hyperplasia

目的 探讨血清总前列腺特异性抗原 (t PSA)、游离PSA (f PSA)、PSA密度 (PSAD )及其f PSA/t PSA比值对前列腺癌 (PCa)及前列腺增生 (BPH )的诊断价值。方法 采用酶联免疫分析方法 (ELISA )检测未经治疗的 62例BPH患者和 2 4例PCa患者血清f PSA、t PSA水平 ,并计算f PSA/t PSA值和PSAD ,对检测结果进行统计学处理。结果 BPH组与PCa组的f PSA、t PSA水平均明显高于对照组 (P <0 .0 1) ;前列腺癌组的f PSA /t PSA值明显小于对照组及前列腺癌增生组 (P <0 .0 1) ;PCa组PSAD明显大于对照组和BPH组 (P <0 .0 1)。结论 检测f PSA/t PSA和PSAD比单一检测f PSA、t PSA可显著提高对PCa诊断的特异性及符合率 ,对前列腺体积较大的BPH和PCa患者 。

Objective To investigate the value of testing the serum t-PSA,free PSA(f-PSA)?PSA density(PSAD)as well as the radio of f-PSA/t-PSA in diagnosing prostatic cancer(PCa) and benign prostate hyperplasia(BPH).Methods The t-PSA and f-PSA in the serum of 62 cases with BPH and 24 cases with untreated PCa were measured with enzyme linked immunosorbent assay(ELISA).Then the ratio of f-PSA/t-PSA and PSAD were figured out.All the data were statistically analyzed.Results The f-PSA and t-PSA were remarkably higher in PCa and BPH group than in the control group(P<0.01).However,the f-PSA/t-PSA of PCa was remarkably lower than that of the BPH and the contrlo group(P<0.01).The PSAD of PCa group was remarkably higher than that of BPH and control group(P<0.01).Conclusion The combinative examination of f-PSA/t-PSA and PSAD can dramatically increase the specificity and accuracy in diagnosis of PCa,compared with single testing of f-PSA or t-PSA.The examination of PSAD is especially important in BPH and PCa with a large volume.