妊高征患者血浆氧化修饰低密度脂蛋白水平及其临床意义

The Plasma Level of Oxidatively ModiGed Low Density Lipoprotein in Patients with Pregnancy Induced Hypertension Syndrome and Its Clinical Significance

目的 探讨妊高征患者血浆中氧化修饰低密度脂蛋白(ox-LDL)的水平及其在妊高征发病中的作用。方法 用ELISA方法检测了44例妊高征患者(妊高征组)和34例同期正常孕妇(对照组)血浆中ox-LDL的含量。结果 妊高征轻、中、重度患者ox-LDL的含量分别为(0.42±0.21)mg/L,(0.54 ±0.33)mg/L和(0.68±0.37)mg/L,明显高于对照组的(0.35±0.12)mg/L(P<0.01)。结论 ox-LDL增加可能是妊高征患者血管内皮细胞损伤的原因之一,可作为妊高征的监测指标之一。

Objective To explore the plasma level of oxidatively modified low density lipoprotein (ox-LDL) in patients with pregnancy induced hypertension (PIH) and its clinical significance. Methods 44 cases with PIH and 34 normal pregnancy with the same pregnancy weeks were detected for ox-LDL by ELISA. Results The plasma levels of ox-LDL in mild , moderate , severe PIH is (0.42±0.21) mg/L, (0.54±0.33) mg/L and (0.68 ±0.37) mg/L, respectively, significantly higher than that in control group ( 0.35±0.12) mg/L (P < 0.01). Conclusion The higher ox-LDL may be one of the causes for endothelial cell damage in PIH and can be used as a predicting index.