雷贝拉唑治疗反流性食管炎临床观察

Clinical Analysis of Curative Effects of Rabeprazole on Reflux Esophagitis

目的 比较雷贝拉唑,六味安消,达喜与法莫替丁,六味安消,达喜治疗反流性食管炎近期疗效及半年复发情况。方法 将80例经内镜等检查诊断为反流性食管炎门诊患者随机分为治疗组和对照组,分别采用雷贝拉唑,六味安消,达喜与法莫替丁,六味安消,达喜治疗6周。结果 治疗组及对照组治疗6周后胸骨后疼痛,反酸,烧心及内镜下食管黏膜炎症恢复总有效率分别为92.5％,72.5%及95.0％,67.5％,半年复发率分别为5％及22.5％,两组比较有效率差异显著(P<0.05)。结论 雷贝拉唑是目前治疗反流性食管炎较为有效的方法。

Objective To compare the half year relapse and efficacy of Rabeprazole with Famotidin in treatment of reflux esophagitis. Methods 80 patients with reflux esophagitis diagnosised by endoscopy randomly divided into the observing group ( Rabeprazole 10mg once daily for 6 weeks) amd the control group(Frmotidin 20mg twice daily for 6 weeks). All patient were reevaluted by endoscopy 6 weeks after treatment Results The effective rate and endoscopic effiency rate and half year of relapse rate 92. 5% , 95. 0% ,5. 0% . for Famotidin group were 72. 5% ,67 ,5% ,22. 5%. There was significant difference between observing group amd control group with X2 test the chinical curative rate corresponded with the endoscopy curative rate. Conclusion The safety and efficacy of Rabeprazole in treatment of reflux esophagitis.