抗病毒药物治疗严重急性呼吸道综合征时机的探讨

Analysis of the optimal opportunity of severe acute respiratory syndrome anti-virus treatment

目的 分析严重急性呼吸道综合征 (SARS)抗病毒治疗的时机 ,为制定SARS抗病毒治疗方案提供参考。方法 采用临床流行病学回顾研究 ,使用SPSS软件分析我院SARS患者的住院病历特点及转归 ,分析不同时间开始抗病毒治疗对T细胞亚群以及预后的影响 ,以初步探讨SARS抗病毒治疗的时机。结果 本文研究发现 ,随着抗病毒治疗开始时间的延迟 ,T细胞亚群的下降程度明显增加 ,病死率逐渐上升 ;发病 3d内开始抗病毒治疗治愈率可达 10 0 % ,而在发病第 4～ 7天时才开始抗病毒治疗的病死率已超过文献报道 ( 6 5 % )水平。结论 发病 3d内开始抗病毒治疗效果比较好。

Objective To analyse the optimal opportunity of severe acute respiratory syndrome (SARS) antivirus therapy,supplying a reference for its treatment projects.Methods Based on the principle of clinical epidemiologic review,the characteristic and prognosis of SARS patients were analysed by SPSS 11 0 software;different starting times of antivirus influencing T cell subset and SARS′prognosis were also analysed to seek for an optimal starting one.Results The descent degree of T cell subset increased obviously if the therapy time delayed.The cure rate could reach 100% if the therapy beginning within the first three days of invasion.While the mortality exceeded the level of the literature reports′ (6 5%) if the therapy beginning from the 4th to 7th of invasion. Conclusion The effect of therapy beginning within the first 3 days of invasion is better.