大剂量盐酸纳洛酮治疗脑卒中昏迷

Clinical Observation on the Efficacy of Large Doses of Naloxone in the Treatment of Coma of Acute Stroke

目的 :研究较大剂量盐酸纳洛酮治疗急性脑卒中昏迷的临床效果。方法 :3 50例急性脑卒中昏迷患者分为观察组 180例与对照组 170例 ,2组均按传统治疗方法治疗 ,治疗组加用大剂量盐酸纳洛酮 3 .2～ 4.0mg静脉滴注 ,每日 2次 ,2周 1个疗程。结果 :观察组总有效率为 87.2 % ,对照组为 71.8% ,2组间比较差异有显著性 (P <0 .0 1)。结论

Objective: To evaluate the clinical effect s of Naloxone in the treatment of patients with coma caused by acute stroke . Method s: three hundred and fifty patients with coma caused by acute stroke were rand omized into Naloxone treatment group (NG,n=180) and conventional treatment g roup (CG, n=170).The patients in the NG group was treated with not only the conventional treatment but also a large dose of Naloxone , 3.2 mg～ 4.0 mg of Naloxone intravenously twice daily for two weeks,in addition to the convent ional treatment as administered to those in the CG group. Results :The effective rate was 87.2% in the NG group and 71.8% in the CG group.There were significant ly difference between the two groups (P<0.01).Conclusion : Naloxone is an ef fective and safe drug for treating coma caused by acute stroke