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P糖蛋白与难治性癫痫 被引量：3

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摘要 难治性癫痫(intractable epilepsy)即一般意义上的药物性难治性癫痫(medically intractable epilepsy),在癫痫中约占20%～30%.长期以来,如何阐明难治性癫痫的产生机制,提高对难治性癫痫的控制率一直是癫痫研究的热点.
作者 李锐 黄远桂
机构地区 第四军医大学西京医院神经内科癫痫研究中心
出处 《卒中与神经疾病》 2003年第5期315-317,共3页 Stroke and Nervous Diseases
关键词 P糖蛋白 难治性癫痫 多药耐药 毛细血管内皮细胞 星形胶质细胞
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献16

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  • 2王学峰,晏勇,吕洋.氟桂利嗪抗癫痫及逆转难治性癫痫病人多药耐受基因的表达[J].中国新药与临床杂志,2001,20(5):363-365. 被引量：11
  • 3Cordon-Cardo (X), Brien JP, Cadals D, et al. Multidrug-resistence gene (P-plycoprotein) is expressed by endothelial cells at blood-brain barrier site. Proc Natl Acad Sci USA, 1989, 86(2):695.
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  • 5Tishler DM, Weinberg KI, Hinton DR, et al. MDR1 gene expression in brain of pateints with medically intractable epilepsy. Epilepsia, 1995, 36(1):1.
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二级参考文献7

共引文献45

同被引文献40

  • 1王本国,廖卫平,罗爱华,孙卫文,苏涛.匹罗卡品癫痫模型及戊四唑点燃模型的行为学、组织学对比研究[J].临床和实验医学杂志,2006,5(3):197-199. 被引量：6
  • 2Wang MJ,Jeng KC.c-Jun N-terminal kinase and,to a lesser extent,p38 mitogen-activated protein kinase regulate inducible nitric oxide synthase expression in hyaluronan fragments-stimulated BV-2 microglia.Journal of Neurommunology,2004,146(1-2):50-62.
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  • 4Langle SL.Neuronal-glial remodeling:a structural basis for neuronal-glial interactions in the adult hypothalamus.Journal of Physiology-Paris,2002,96(3-4):169-175.
  • 5Morimoto K.Kindling and status epilepticus models of epilepsy:rewiring the brain.Progress in Neurobiology,2004,73(1):1-60.
  • 6Marchi1 N.Significance of MDR1 and multiple drup resistance in refractory human epileptic brain.BMC Medicine,2004,9(2):37.
  • 7Osesa JP.Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol.Brain Research Bulletin,2004,64(3):237-242.
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  • 10Scorza CA,Arida RM.Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy.Neuroscience Research,2005,51(3):285-291.

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卒中与神经疾病
2003年 第5期

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