不同雾化吸入方案对肺切除患者术后痰液白细胞的影响

Influence of Different Aerosol Inhalation Protocols on Sputum Leukocytes of Patients after Pneumonectomy

目的探讨适用于肺切除术后患者的更理想的雾化吸入方案,以减轻呼吸道炎性反应,预防术后肺部并发症.方法采用正交设计实验方案,4个研究因素即雾化吸入的湿化剂、祛痰剂、解痉药和抗生素,每因素为3个水平,选用L27(34)正交设计表,按确定的实验方案随机分配给入选患者.观察患者吸入不同雾化液时术后1～5 d痰液白细胞水平的变化.结果雾化吸入不同湿化剂、祛痰剂、解痉药、抗生素的患者术后1～5 d痰白细胞水平均无显著性差异(P＞0.05).结论不同雾化吸入方案对减轻开胸术后患者呼吸道炎性反应的作用不够理想,因而有必要探讨更有效的雾化吸入方案.

Objective To explore a more ideal aerosol inhalation protocol for pneumonectomic patients so as to lessen airway inflammatory reactions and prevent postoperative pulmonary complications. Methods By using an orthogonal study design, four research factors including aerosol humidifying agents, expectorants, antispasmodics and antibiotics were randomly administered to patients at 3 levels for each factor using L_(27) (34) form as designed. Sputum leukocyte changes after inhalation of different aerosol protocols on1 to 5 P. O. D were observed. Results No significant differences in sputum leukocytes were found in patients who inhaled different aerosol humidifying agents, expectorants, antispasmodics and antibiotics andtheir different scheme ( P>0.05 ). Conclusion The aerosol inhalation protocols available are inadequate to alleviate airway inflammatory reactions, and it is necessary to explore a new and more effectiveprotocol for this purpose.