依诺肝素对老年不稳定型心绞痛血浆sICAM-1水平的影响

The change of plasma soluble adhesion molecule-1 in the aged with UAP and influence on enoxaparin sodium

目的:探讨老年不稳定型心绞痛(unstable angina pectoris,UAP)患者血浆可溶性细胞间粘附分子-1(soluble intercellu—lar adhesion molecule-1,sICAM—1)水平变化及依诺肝素干预对其影响。方法:将118例老年UAP患者随机分成依诺肝素治疗组和非治疗组。治疗组应用依诺肝素40mg每日2次皮下注射,疗程5d;治疗前后和对照组采肘静脉血测sICAM-1水平。结果:老年UAP患者血浆sICAM-1水平明显高于对照组(P<0.05),依诺肝素治疗后sICAM-1水平明显下降(P<0.05)。结论:sICAM-1参与了老年UAP病理过程,依诺肝素对血管内膜损伤有保护作用。

Objective To explore the changes of plasma sICAM-1 in the aged with UAP intervened by enoxaparin sodium. Method 118 cases in the aged with UAP were divided into two groups including drug treatment and no-drug treatment,the former was intervened by enoxaparin sodium.sICAM-1 was measured after and before enoxaparin sodium treatment and normal control. Result sICAM-1 in the aged with UAP was significant higher than that in normal control(P<0.05). sICAM-1 in the heparin treatment was significant lower than that before treatment (P<0.05). Conclusion sICAM-1 may involve in the pathogenesis of the aged with UAP, having protective effect on endanium injury.