曲马多对全身麻醉苏醒期和气管拔管反应的影响

The effect of intravenous tramadol on the reaction of tracheal extubation and Anesthesia recovery period

目的:观察全身麻醉苏醒期静脉注射曲马多对全身麻醉苏醒、气管拔管反应的影响。方法:选择ASA Ⅰ～Ⅱ级患者120例,按随时平均分为C组(对照组)、T组(研究组),两组在手术结束前10min分别静脉注射0.9％生理盐水、曲马多(2mg/kg)稀释液5ml,在2min内注射完毕,3min后减浅麻醉,观察比较两组患者的苏醒速度,气管拔管反应及全麻并发症。结果:两组在完成指令性动作和拔除气管导管的时间上无差异;但在拔管时C组患者的心率、血压变化显著高于T组;监测脉搏氧饱和度(SPO2),拔管时即刻C组低于T组,有统计学意义,拔管后C组亦低于T组,但无统计学意义;T组并发症显著少于C组。结论:在全身麻醉苏醒期应用一定剂量曲马多不影响患者苏醒,不抑制呼吸而且可以抑制气管拔管反应并有助于减轻苏醒后疼痛,减少全麻并发症。

Objective To observe the effect of trmadol on anesthesia recovery period and reaction of tracheal extubation. Method 120 ASA I-II patients were randomly allocated to two groups .About 10 minutes before the end of surgery ,0.9% normal saltine solution (Group C) or tramadol with a dose of 2 mg/kg (Group T) was intravenously infused ,each of which was diluted into 5 ml , and the depth of anesthesia was weakened 3 minutes later .The time of recovery was recorded ,and the reactions of tracheal extubation and the side-effects were also observed. Results In group C ,heart rate and blood pressure was increased significantly compared with that in group T;arterial oxygen saturation was lower severely than in group T at the time of extubation .while 5 minute later , the difference was insignificant .The time recoverying for response to command and for tracheal extubation was not different between two groups .Side-effects were more in group C than in group T. Conclusion Tramadol intravenously infused with a dose of 2 mg/ kg has little effect on respiration and recovery.restrains the reaction of tracheal extubation and releases side-effect of general anesthesia .So it can be used safely and satisfactorily during anesthesia recovery period .