心肌缺血预适应对急性心肌梗死影响的观察

Effect of myocardial ischemic preconditioning on acute myocardial infarction

目的:探讨心肌缺血预适应对急性心肌梗死(AMI)临床表现及其预后的影响。方法:根据AMI前有无心绞痛发作分为预缺血组和无预缺血组,分组观察AMI患者血清肌酸磷酸激酶(CPK)峰值,住院期间并发症(心衰、心源性休克、严重心律失常),以及住院期间心性病死率。结果:预缺血组血清CPK峰值明显低于无预缺血组(P<0.05),住院期间心源性休克及严重心律失常发生率明显低于无预缺血组(P<0.05)。结论:心肌缺血预适应可减轻心肌坏死程度,缩小梗死面积,并减少AMI并发症的产生。

Objective: To investigate the clinical and prognostic effects of myocardial ischemic preconditioning on acute myocardial infarction. Methods: According to patient ever having of not having angina pectoris before occurring acute myocardial infarction (AMI), the patients with AMI were divided into two groups: group A (ischemic preconditioning group, the patients ever having angina pectoris before occurring AMI) and group B (no ischemic preconditioning group, the patients not ever having angina pectoris before occurring AMI). The peak of serum creatine phosphatase kinase (CPK). the incidences of complications (heart failure, cardiac shock and severe arrhythmia) and cardiac mortality during hospitalization were detected in two groups. Results: The peak of serum CPK, incidence of cardiac shock and severe arrhythmia during hospitalization were lower in group A than those of group B (P<0. 05). Conclusion: Myocardial ischemic preconditioning may decrease the extent of myocardial infarction, myocardial infarction size and reduce the complication occurrence of AMI.